Advanced Biology through Inquiry Teacher Guide - PS-2852



In an advanced or AP Biology course, classroom time is a precious commodity.  That's why PASCO's Advanced Biology through Inquiry lab manual provides accurate data collection and analysis, editable labs that can be seamlessly integrated into your individual curriculum and continual assessment to ensure that students are engaged and critically thinking throughout the activity.

Over 22 challenging, standards-based lab activities that include inquiry extensions.  All are editable to suit the needs of your students or to better coordinate with your classroom lectures.  All labs are also accompanied by a compete teacher's guide with intensive background information and "teacher tips" as well as multiple choice questions to help students gain confidence for those critical standardized exams.

PASCO's Advanced Biology through Inquiry Teacher Guide was recently recognized as a finalist in the 2015 REVERE Awards!


  • Advanced labs for students in AP Programs.
  • Opportunities to assess student comprehension before, during and after the activity.


  • Advanced labs for students in AP Programs
  • Editable Word files for each student version
  • Electronic storage device containing all information in electronic format
  • Experiments

    Big Idea 1

    Artificial Selection

    Students follow the growth and development of Wisconsin Fast Plants and determine if limiting cross-pollination to certain plants with a desired trait affects the frequency of that trait in the second generation.

    BLAST Bioinformatics

    Students analyze the DNA and protein sequences of beta globin of five mammalian species to determine their evolutionary relatedness.

    Mathematical Modeling of Evolution

    Students work with a mathematical model and computer simulation to explore how inheritance patterns and gene frequencies change in a population.

    Population Genetics

    Students determine their phenotype for the PTC (phenylthiocarbamide) tasting trait and use class data to derive allele frequencies for a population.

    Big Idea 2

    Animal Behavior

    Students use a choice chamber to test the response of fruit flies to different stimuli and determine if there is a significant change in their behavior.


    Students use a pH sensor to investigate the diffusion of hydrogen ions through a semipermeable membrane, comparing the rates of diffusion for two solutions that differ in their acidity.


    Students use a conductivity sensor to explain the results of different concentrations of salt water on plant tissue before they design an experiment to compare the water potential of different plant tissues.

    Big Idea 3


    Students use physical models of chromosomes to explore meiosis and genetic variation, and use cross over rates observed in Sordaria to calculate gene distance from the centromere.


    After learning the technique for growing roots and preparing root tip squashes for microscope analysis, students observe the root tips for evidence of mitosis and statistically analyze the data.


    Students transform bacteria with a plasmid that contains an ampicillin resistance gene and a gfp gene that is regulated so only some transformed cells produce the green fluorescent protein.

    Big Idea 1, 2, 4

    Cellular Respiration

    Students use a carbon dioxide gas sensor to investigate the rate of cellular respiration of germinating seeds.

    Enzyme Activity

    Students use an oxygen gas sensor or pressure sensor to investigate the catalyzed decomposition of hydrogen peroxide by catalase.

    Big Idea 2, 3, 4

    Understanding Inherited Mitochondrial Disorders

    Students use pedigree analysis and DNA analysis (electrophoresis) to confirm or refute the initial diagnosis of MELAS for two patients.

    Big Idea 2, 3


    Students use a colorimeter to determine which extracellular fluid is hypertonic to a model cell and which solution is hypotonic.

    Big Idea 1, 2

    Cell Size

    Students use temperature probes to measure the effect of cell size on cell cooling rate using cubes of potato tissue.

    Big Idea 3, 4


    Students use multiple temperature probes simultaneously to investigate the body’s ability to maintain homeostasis when subjected to a cold stimulus.

    Sickle Cell Gene Detection

    Students use electrophoresis to analyze DNA samples from a child and the child’s parents to determine if the child has inherited a mutation in the gene for hemoglobin B.

    Big Idea 2, 4

    Energy Dynamics

    Students use EcoChamber containers and a carbon dioxide gas sensor to estimate energy flow and carbon cycling within a variety of detritus-based ecosystems.


    Students use an ethanol sensor to determine the ability of yeast to use different types of carbohydrates—sucrose and starch—for fermentation.


    Measure the rate of photosynthesis of a leaf using the carbon dioxide gas sensor.

    Plant Pigments

    Students analyze spinach pigments and chloroplasts using paper chromatography, a colorimeter, and a spectrometer to understand how plants capture light for photosynthesis.


    Students use a low pressure sensor (barometer) and a weather sensor to investigate the rate of transpiration in plants under normal and humid conditions.

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